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Professor and Chair,
Department of
Neurobiology and Developmental Sciences; University of Arkansas for Medical
Sciences,
Little Rock, AR
Contact me at: childsgwenv@uams.edu
or,
gvchilds@mac.com, which will reach my IPHONE.
The research in my laboratory is focused
on the regulation of specific anterior pituitary cells by neuroendocrine peptides and
growth factors. Most recently, we are focused on the role of leptin in the
regulation of pituitary gonadotropes and growth hormone. We have
received National Institute of Health and National Science
Foundation funding. (Formerly
Gwen C. Moriarty, Ph.D.)
What's new at this site?
Updated CV (April, 2008)
Updated page for in situ hybridization.
CAMPUS ADDRESS:
Gwen V. Childs, Ph.D.
Professor and Chair
Department of Neurobiology and Developmental Sciences
College of Medicine
University of Arkansas for Medical Sciences
4301 W. Markham St; Slot 510
Little Rock, AR, 72205
(501) 686-7020
web page: www.cytochemistry.net/childs/Childs.htm
Email: childsgwenv@uams.edu
or gvchilds@mac.com

Summary of Training
and Academic Positions:
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1966: B.A., Biology, Whitman College, Walla Walla, Washington.
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1972: Ph.D., Anatomy, University of Iowa, Iowa City, Iowa
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1972: Assistant Professor of Anatomy, University of Nebraska
Medical Center, Omaha, Nebr
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1976: Associate Professor of Anatomy, Northwestern University
College of Medicine, Chicago, Ill |
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1981-April, 2000: Professor of Anatomy, University of Texas Medical Branch,
Galveston, TX
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1992-2000: Vice-Chair, Department of Anatomy and Neuroscience
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1992-2000: Program Director,
Cell
Biology Graduate Program at the University of Texas Medical Branch
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1997-March, 2000: Coordinator, Basic Science Core, (New)
Integrated Medical Curriculum,
University of Texas Medical Branch
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April, 2000: Professor and Chair,
Department of
Neurobiology and Developmental Sciences,
University of
Arkansas for Medical Sciences
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Note: I began my academic life as Gwen Childs
Moriarty. My publications from 1972-1977 are authored by Gwen C. Moriarty.


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Dynamic changes in
gonadotropes
during
the reproductive cycle.
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Are
growth hormone
cells
co-gonadotropes?
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The effects of
epidermal
growth factor
on pituitary corticotropes and gonadotropes.
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The effects of stress on the
expression of pituitary
epidermal growth factor
.
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Regulation and secretion of pituitary
nerve growth factor
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Stimulus secretion coupling in
corticotropes: role of ion channels in
signaling
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Significance and regulation of
Anterior pituitary leptin to the reproductive system (page under
construction) |
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Regulation of monohormonal
gonadotropes, expressing only one beta subunit mRNA (page under
construction) |
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Significance and regulation of
anterior pituitary leptin as a modulator of Growth hormone secretion
(page under construction) |

Graduate students 1994-present
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James
Patterson (M.D. Ph.D. student; completed Ph.D in 1994) Now doing a residency in
Psychiatry at the University of Texas Medical Branch. |
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Xuemo Fan
(completed
Ph.D. in 1994)
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Jennifer
Armstrong
(completed Ph.D. in 1997)
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Jiangang
Xie
(completed Ph.D. in 1998)
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Iris
MacDuffie (M.S. student in Nutrition at UAMS) |
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Mary
Iruthayanathan, M.D. (Ph.D. student in Anatomy and
Neurobiology) |
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Chris Crane, M.S. (Master's
program); now an Honors Medical Student |
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Zachary Brodrick, M.S.
(Master's program). |

Special techniques used in laboratory
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Immunogold cytochemistry
for
detection of hormones and growth factors
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Affinity
Cytochemistry
for detection of receptors
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In situ hybridization
to detect messenger RNA
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Dual labeling
for
detection of receptors or mRNA and antigens (or two antigens)
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Centrifugal
elutriation
to enrich and purify pituitary corticotropes gonadotropes, and growth hormone cells.
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siRNA silencing of pituitary leptin.
Transfection of primary pituitary cell cultures |
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Cre-loxP technology applied to selectively
knockout genes in gonadotropes or somatotropes. Deletion
mutants of leptin receptors are now being produced. |
We also use more routine technology like
electron microscopy, cytology, radioimmunoassay, image analysis, enzyme immunoassay, and
tissue culture. Most molecular biology techniques such as qRT-PCR, RNA and
DNA extraction, genotyping are ongoing in core facilities,
Last updated:
04/29/08
URL Address: http://www.cytochemistry.net/childs/Childs.htm
email:
gvchilds@mac.com or childsgwenv@uams.edu
© copyright 1995 Gwen V. Childs, Ph.D.
visitors since original page went online: 10/23/00
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