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Gwen V Childs Academic Program

Gwen V. Childs, Ph.D.,FAAA

Formerly Gwen C. Moriarty, Ph.D.

Professor and Chair, Department of Neurobiology and Developmental Sciences; University of Arkansas for Medical SciencesLittle Rock, AR

Contact me at:  childsgwenv@uams.edu or  gvchilds@me.com

The research in my laboratory  is focused on the regulation of specific anterior pituitary cells by neuroendocrine peptides and growth factors. Most recently, we are focused on the role of leptin in the regulation of pituitary gonadotropes and somatotropes.  We have received National Institute of Health and National Science Foundation funding and are currently supported by R01 HD059056-05  

What's new at this site?

CAMPUS ADDRESS:
Gwen V. Childs, Ph.D., FAAA
Professor and Chair
Department of  Neurobiology and Developmental Science
College of Medicine
University of Arkansas for Medical Sciences
4301 W. Markham St; Slot 510
Little Rock, AR, 72205
(501) 686-7020

web page: www.cytochemistry.net/childs/Childs.htm
Email: childsgwenv@uams.edu or gvchilds@me.com

 Summary of Training and Academic Positions

  • 1966: B.A., Biology, Whitman College, Walla Walla, Washington.
  • 1972: Ph.D., Anatomy, University of Iowa, Iowa City, Iowa
  • 1972: Assistant Professor of Anatomy, University of Nebraska Medical Center, Omaha, Nebr
  • 1976: Associate Professor of Anatomy, Northwestern University College of Medicine, Chicago, Ill
  • 1981-April, 2000: Professor of Anatomy, University of Texas Medical Branch, Galveston, TX
  • 1992-2000: Vice-Chair, Department of Anatomy and Neuroscience
  • 1992-2000: Program Director, Cell Biology Graduate Program at the University of Texas Medical Branch
  • 1997-March, 2000: Coordinator, Basic Science Core, (New) Integrated Medical Curriculum,  University of Texas Medical Branch
  • April, 2000: Professor and Chair, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences

 Note: I began my academic life as Gwen Childs Moriarty. My publications from 1972-1977 are authored by Gwen C. Moriarty.

State and National Committee or Consulting Service

Honors (since 2000)

h-index calculation (August, 2014)

  • The h-index as of August, 2014 shows, that I have 44 publications that have received 44 or more citations with an average of 30 citations per publication.
  •  When abstracts in the list are omitted, the average increases to 35.7 citations per paper.
  • Our papers have been cited 5956 times; 5038 citations are from other authors.

Press Releases

ResearchGate Statistics

  • RG score: September 8, 2014--41.77
  • Total impact:  597.08
  • 45-78 Publication and Profile views/week
  • ResearchGate Site  for Gwen Childs

Specific Projects

  • Dynamic changes in gonadotropes during the reproductive cycle.
  •  Are growth hormone cells co-gonadotropes?
  •  The effects of epidermal growth factor on pituitary corticotropes and  gonadotropes.
  •  The effects of stress on the expression of pituitary epidermal growth factor .
  •  Regulation and secretion of pituitary nerve growth factor
  •  Stimulus secretion coupling in corticotropes: role of ion channels in signaling 
  • Significance and regulation of Anterior pituitary leptin to the reproductive system (page under construction)
  • Regulation of monohormonal gonadotropes, expressing only one beta subunit mRNA (page under construction)
  • Significance and regulation of anterior pituitary leptin 
  • Significance of leptin receptors on pituitary somatotropes and gonadotropes.

Graduate Students 1994- Present

  • James Patterson (M.D. Ph.D. student; completed Ph.D in 1994) Now doing a residency in Psychiatry at the University of Texas Medical Branch.
  • Xuemo Fan (completed Ph.D. in 1994)
  • Jennifer Armstrong (completed Ph.D. in 1997)
  • Jiangang Xie (completed Ph.D. in 1998)
  • Iris MacDuffie (M.S. student in Nutrition at UAMS)
  • Mary  Iruthayanathan, M.D. (completed Ph.D. in 2006)
  • Chris Crane, M.S. (Master's program; Honors Medical Student; Completed MD in 2010
  • Zachary Brodrick, M.S. (MS, completed in 2008, MD Completed in 2013).
  • Angela Odle, Ph.D. (Ph.D. Completed in 2014)
  • Melody Allensworth (Ph.D. Program, 2011-present)

Special techniques used in laboratory

  • Immunogold cytochemistry for detection of hormones and growth factors
  •  Affinity Cytochemistry for detection of receptors
  •  In situ hybridization to detect messenger RNA
  • Dual labeling for detection of receptors or mRNA and antigens (or two antigens)
  • Centrifugal elutriation to enrich and purify pituitary corticotropes gonadotropes, and growth hormone cells.
  • siRNA silencing of pituitary leptin.  Transfection of primary pituitary cell cultures
  • Cre-loxP technology applied to selectively knockout genes in gonadotropes or somatotropes.  Deletion mutants of leptin receptors are now being produced.

We also use more routine technology like electron microscopy, cytology, radioimmunoassay, image analysis, enzyme immunoassay, and tissue culture. Most molecular biology techniques such as qRT-PCR, RNA and DNA extraction, genotyping are ongoing in core facilities.

 This form of the original page went online: 10/23/00

 For more information, contact:

Gwen Childs, Ph.D.,FAAA
Professor and Chair
Department of Neurobiology and Developmental Sciences
University of Arkansas for Medical Sciences
Little Rock, AR 72205

For questions, contact this email address

http://www.cytochemistry.net


© Gwen Childs Jones, Ph.D. 1995